Abstract: The formation of any wisdom has premises. Mao Zedong's wisdom of methodology has its theoretical origin and practical basis. Mao Zedong laid stress not only on the inheritance and development of Marxist methodology,but also on the creation and innovation of methodology,summarization of methods based on the solution to Chinese concrete problems in the course of revolution and construction. Mao Zedong's wisdom of methodology is by nature sinicization of Marxist methodology.