Abstract: The spiritual genealogy of Chinese Communists was gradually formed and developed during the century-long process of the Party leading the people in revolution, construction and reform, and it has strong appeal and cohesion. Youth are the future of the country and the hope of the nation, and they are an important force in the construction of the Guangdong-Hong Kong-Macao Greater Bay Area. Integrating the spiritual genealogy of Chinese Communists into the exchanges and integration among youth from Guangdong, Hong Kong and Macao can promote the ideological guidance and value shaping of youth, and strengthen the cultivation of ethnic unity and national identity. However, due to historical reasons and differences in systems among Guangdong, Hong Kong and Macao, the exchanges and integration of youth still face many challenges. To this end, based on the actual situation, it is necessary to explore the improvement path of integrating the spiritual genealogy of Chinese Communists into the exchanges and integration among the youth from Guangdong, Hong Kong and Macao. That is, to establish a science and technology innovation center for the exchanges and integration among the youth from Guangdong, Hong Kong and Macao by building a collaborative and interactive system of “government, schools, enterprises and society” among Guangdong, Hong Kong and Macao, and set up a new media platform for the exchanges and integration among the youth from Guangdong, Hong Kong and Macao. These practical models can help promote high-quality development of the Guangdong-Hong Kong-Macao Greater Bay Area and the realization of the Chinese Dream of the great rejuvenation of the Chinese nation.