Abstract: At present, the construction of cultural leadership in China is encountering challenges such as the influence of some wrong cultural trends abroad, the lack of people’s identity in domestic ideology, as well as the deviation of some literary works from mainstream values and the weakness of international discourse, etc. Facing the challenges and threats of diverse and complex cultural phenomena, it is necessary to further consolidate and enhance the cultural leadership in China. Xi Jinping’s remarks on the construction of cultural leadership provide us important theoretical guidance. On the basis of inheriting and developing the cultural leadership of his predecessors and analyzing the situation at home and abroad, Xi Jinping has repeatedly discussed and gradually built up a system of cultural leadership construction. The system includes adhering to Marxism, mastering ideological leadership, strengthening the Party’s leadership of literary work, firmly asserting cultural confidence, and improving cultural soft power, etc. It provides theoretical innovation for China to firmly grasp cultural leadership and discourse power and promote the “two combinations” of sinicization of Marxism. It also provides a new theoretical basis for cultural inheritance and cultural development, and contributes to the construction of a socialist cultural power in China.