Abstract: The courage to self-revolution is the most distinctive character of the Communist Party of China, which is also distinguished from other political parties. In one hundred years, the communist party of China always adhere to and develop a thorough self-revolutionary spirit, face to the problems and expel evils, purify the body and gradually achieve self-perfection and self-improvement. These measures have accumulated valuable experience for strengthening the Party’s self-revolution in the new era. In terms of organizational experience, we should adhere to the leadership of the party to provide solid foundation for the leadership of the revolution itself. In terms of revolutionary experience, the integration of “two revolutions” is the revolutionary source of self-revolution. In terms of target experience, we should grasp the “key minority” for the clear crowd orientation of self-revolution. In terms of experience in methods, the way of running the party in parallel with thought and system builds solid ideological and system foundation for self-revolution.