Abstract: In recent years, with the high attention paid by the state, the innovation and entrepreneurship education in local universities has been developed rapidly. However, there are still many problems such as scattered investment, lack of collaboration, disordered practical activities, and scarce resonant organization mechanism, which lead to the lack of long-term mechanism and too difficult to form its own brand and characteristics. In order to solve the problems, it is proposed that local universities may make full use of their own regional and disciplinary advantages, intergrate limited human and material resources, improve management and service quality, and explore to build a collaborative resonance education mechanism with their own characteristics, which will make the practice activities transformed from disordered to ordered, from impact to self-organized, from unsystematic to synergy and resonance and improve the quality of innovation and entrepreneurship education practice.