Abstract: Scientific and technological innovation plays a vital role in achieving the goal of basically realizing socialist modernization by 2035. In the process of scientific and technological innovation, we should firmly hold the concept of “let science and technology benefit mankind”. We must also truly allow technological innovation to promote economic development, enhance people’s welfare, spread the spirit of science, promote the intelligence of the people, enhance people’s self-confidence, inspire people’s cohesion, stimulate patriotism, understand the condition of the people, promote system improvement, optimize the rule of the people, and finally reflect the affinity to the people of technological innovation. Xi Jinping’s relevant discussion on the affinity to the people of scientific and technological innovation not only laid the foundation for scientific and technological innovation in new era, but also pointed out the direction of its development.