Abstract: The realization of communism needed a long-term realistic movement was expounded by Marx in the Economic and Philosophical Manuscripts of 1844. Only by sublating private property and solving the problem of labor alienation, man and man, man and nature will achieve a final reconciliation. Really, mankind can be liberated in essence. The Communist thought of Marx in the manuscript possessed great theoretical features and practical value, and provides a momentous theoretical basis for the construction of socialism with Chinese characteristics.