Abstract: At present, the epidemic situation is at the most critical moment, and it is also a graduation season. The prevention and control of major epidemic situation may have a great impact on the employment of college graduates. To do a good job in the employment of graduates, colleges and universities should take the initiative and issue effective measures and methods. In the face of the major epidemic situation, Nanchang Hangkong University focuses on “one center”, improves “two mechanisms” and strengthens “three measures”. It has certain reference significance for other colleges and universities to do a good job in employment.