Abstract: The Communist Manifesto is a programmatic document of scientific socialism, and is an important source of the thought of the community of human destiny. The Communist Manifesto reveals the historical roots and practical basis of the ideological origin of the community of human destiny, point out that the value of building a community of human destiny is to seek common interests for all mankind, ultimately realize human freedom and comprehensive development. The Communist Manifesto also clarified that the construction of a community of human destiny must be based on the independent liberation of the oppressed nations, at the same time, the concepts of advocating class cooperation and strengthening universal exchanges were proposed, has important theoretical value and significance of the times, especially for dealing with economic and civil relations in global governance, promote economic equality and win-win cooperation, avoiding the conflict of civilizations has important practical significance.