Abstract: The micro platform represented by WeChat public number has become the main carrier of campus culture dissemination and publicity. As the main unit of inheriting, developing, interpreting and disseminating Marxist theory, the college of Marxism in universities should actively use WeChat public number to continuously expand its theoretical dissemination power. As WeChat public number of the college of Marxism is still in the construction stage, the theoretical dissemination power is relatively weak, which is related to the narrowing and vagueness of its own function positioning, the lack of self-consciousness of ideological and political teachers’ participation in theoretical dissemination, and the imperfect mechanism of dissemination effect. It is necessary to improve the theoretical dissemination power of WeChat public number of the college of Marxism in universities from many aspects, including accurate function positioning, strengthening content construction, and building an effective incentive and feedback mechanism and others.