Abstract: Based on the travel agencies' relevant data of 31 provinces in 2013, using the method of spatial econometrics, the paper analyzes the spatial layout of travel agencies. The result shows that the amount of provincial travel agency layout is of spatial autocorrelation, and the amount of provincial travel agency layout varies obviously between the eastern and western regions. The layout has a strong positive correlation with macroeconomic indicators, such as, urbanization rate, the per capita GDP, but weak positive correlation with business performance indicators, such as, average revenue, average profit. Then, adopting the way of principal component analysis (PCA), the paper discusses the factors influencing provincial travel agencies comprehensive strength, results show that the spatial layout of the amount of travel agencies is not strictly positive correlation with the travel agency's business performance, offers some beneficial reference in optimizing the spatial layout of the travel agency industry in China.