Abstract: It has become an important task for the regionalized development of colleges with industry characteristics to construct the ecosystem of innovation and entrepreneurship education for college students under the new normal conditions guided by the theory of " mass entrepreneurship, mass innovation”. Through the analysis of the connotation, elements and regional development model of innovation and entrepreneurship education ecosystem in colleges and universities, it can be seen that the ecosystem of innovation and entrepreneurship education in universities with industry characteristics is relatively independent. Its operation depends on various elements such as local government education policy, university double-creation education model, production and education integration platform, entrepreneurship consultation and service, industry development think tank, entrepreneurship cooperation and funding. The inevitability of the regionalization development of industry-specific universities is discussed on the basis of the analysis of the co-evolution relationship among local governments, industry enterprises, local universities and regions. Finally, taking Nanchang Aeronautical University as a case study, the process of building an innovative entrepreneurship education ecosystem with aviation industry characteristics and the regionalized development strategy of the university are described comprehensively, which are based on the goal of improving college students’ innovative practical ability and the quality of personnel training. The conclusion of the study provides an effective way for the regionalization of universities with industry characteristics.