Abstract: At a high pressure vapor-liquid equilibrium cell using liquid phase circulating, the vapor-liquid phase equilibrium data of the supercritical carbon dioxide-ethyl acetate binary system were measured at 313.15 K, 318.15 K and 323.15 K,and at the pressures ranging from 7.14 MPa to 9.02 MPa, and the vapor-liquid phase equilibrium data of the supercritical carbon dioxide-ethyl acetate-water ternary system were measured at 313.15 K, 318.15 K and 323.15 K, and at the pressures ranging from 8.89 MPa to 11.91 MPa. The effects of operational conditions (temperatures and pressures) on the mole fractions of ethyl acetate in supercritical fluid phase, the separation factors and the mole fractions of ethyl acetate (free of CO₂) in the supercritical fluid phase were discussed.