2, 6-二(5-叔丁基邻羟基苄基)-4-叔丁基苯酚合成方法的改进

Improvment Synthesis of 2, 6-bis(5-tert-butylsalicyl)-4-tert-butylphenol

摘要: 本文以改进的方法通过二步合成了2,6－二(5－叔丁基邻羟基苄基)－4－叔丁基苯酚,在第一步,由对叔丁基苯酚和甲醛在碱性条件下合成2,6－二羟甲基－对叔丁基苯酚,产物未作完全纯化直接用于第二步反应;第二步反应以对甲苯磺酸作催化剂,与文献相比,总产率由18%提高至43%,处理更容易.

Abstract: In this paper,A improved method of synthesis of 2,6-bis(5-tert-butylsalicyl-4-tert-butyl.phenol was described.In first step,2,6-bis(bydromethyl)-4-tert-butyphenol has been prepared from p-tert-buty(phenil and formaldehyde in basic system(NaOH),and the end product was used directly in second step.In second step,the title compound was synthesized from (I) and p-tert-butylphenol with HCl or p-toluen sulfonic acid as catalyst.the total yield was increased from 18%(reported in previous literature)to 43%,and the treatment of the product was easier.