Abstract: Ti₇₅Al₁₀V₅Cr₅Nb₅ high-entropy alloy was prepared by a combination of high energy ball mill alloyed (MA) and discharge plasma sintering (SPS). The influence of high energy ball milling time on the microstructure and mechanical properties of SPS sintered Ti₇₅Al₁₀V₅Cr₅Nb₅ high-entropy alloy was studied, and the optimal milling process parameters were obtained. The results show that Ti₇₅Al₁₀V₅Cr₅Nb₅ powder can be allotized by high-energy ball milling in the order of Al, Ti, Cr, V, Nb. In the process of high-energy ball milling (MA), the hexagonal close-packed phase appeared when the milling time was more than 10 hours. After discharge plasma sintering, the microstructure of the alloy was dominated by fine grains, and the phase structure changed to body-centered cubic phase. The hardness of Ti₇₅Al₁₀V₅Cr₅Nb₅ high entropy alloy increases with the increase of milling time, and the compressive plasticity increases first and then decreases. The optimal ball milling time is 10 h, at which the compressive strength is 2340 MPa and the reduction is 2.65%.