Abstract: ANSYS finite element software is used to establish many kinds of diagonal square pyramid grid models, such as no opening, single opening, double opening, etc. Through simulation calculation, the variation law of its static characteristics with the opening area and opening position is examined, and the reinforcement scheme design and effectiveness verification are carried out for the weakening of bearing capacity caused by opening. The results show that, compared with the grid structure without holes, when the center of the grid structure is opened with a single hole, the maximum vertical displacement of the structure increases significantly, and the maximum tensile and compressive stress of the structure increases slightly, but basically with the increase of the hole area, the displacement has a decreasing trend, and the stress fluctuates slightly. The best reinforcement scheme for single opening grid is to add members in the mid span of the plane of the bottom chord around the structure, which can significantly improve the structural stiffness and greatly reduce the stress of the grid. The calculation of the grid structure with the same opening size shows that opening along the diagonal direction of the grid structure has little impact on the structural stiffness and bearing capacity. The single opening grid structure should be opened in the diagonal direction and away from the center of the structure, while the double opening grid structure should be opened in the diagonal direction and close to the corner of the structure.