Abstract: To explore the effects and application of the combination method of “Internet+” and OBE teaching method in the teaching of “Traditional Chinese Medicine” of clinical medicine speciality, the grade 2020 of clinical medicine was selected as the research object, with the 45 students in the class three determined as the control group by simple random sampling , and 44 students in the class four determined as the experimental group. The experimental group implemented the new teaching method of the combination of “Internet+” and OBE, and the control group chose the traditional classroom teaching mode. Theoretical scores and satisfaction questionnaires were mainly adopted to evaluate the teaching effect. The results show that the average scores of regular exams, midterm exams, final exams, and comprehensive scores of the experimental group are higher than those of the control group. The satisfaction of the experimental group in teaching methods and other aspects was significantly higher than that of the control group, while no significant difference in satisfaction of enhancing innovative ability. It can be seen that the application of the combination method of “Internet+” and OBE teaching method in the teaching of “Traditional Chinese Medicine” in schools of western medicine improve the teaching effect and student satisfaction, providing a new idea for the reform of “Traditional Chinese Medicine” teaching in schools of western medicine.