Abstract: According to the new requirements for graduate talent cultivation set by the government, the field of rheumatology and immunology is experiencing rapid development and iteration. Active learning is considered as one of the important directions for the graduate education in the future. Currently, there is insufficient emphasis on active learning in the field of rheumatology and immunology in our country, especially in the era of the Internet where digital teaching is rapidly advancing. As a result, there are certain obstacles in the implementation of teaching, including teachers’ resistance to changing educational methods, lack of initiative among learners, potential social risks, and the limited application of the Internet in discipline-specific education. This paper conducts theoretical analysis based on the direction of active learning and proposes corresponding optimization strategies, including providing teacher training to help them better adapt to the changes, motivating learners to improve their initiative, addressing social risks, and advocating for the popularization and application of Internet technology. Through these optimization strategies, the effectiveness of active learning in the field can be further enhanced, thus promoting the comprehensive cultivation of graduate talents in rheumatology and immunology.