Abstract: The aerodynamic performances of the aerospace plane model were numerically simulated using polyhedral mesh, trim mesh and tetrahedral mesh in this work. The obtained aerodynamic coefficients were compared with the corresponding experimental results, and the accuracy of different meshes on the aerodynamic calculation was investigated through the calculation error. It was found that the three types of meshes could simulate the aerodynamic coefficients of aerospace plane accurately, among which the polyhedral mesh had the best accuracy on aerodynamic calculation, while having the lowest numerical error of aerodynamic coefficients. By contrast, the numerical error of aerodynamic coefficients calculated by tetrahedral mesh was highest. However, in some cases, the ratio of lift coefficient to experimental value calculated by tetrahedral mesh was close to the ratio of resistance coefficient to experimental value, making the lift to drag ratio closer to the experimental result. In addition, by comparing with the experimental schlieren images, the three meshes could simulate the flow field structure of the aerospace plane model accurately. Among them, the polyhedral mesh and trim mesh had better resolution capacity of shock waves than the tetrahedral mesh. However, with the increased attack angle, the polyhedral mesh had better performance in capturing shock waves around the aerospace plane model, while trim mesh could capture the internal flow structures more accurately.