Abstract: It is an important reform direction to incorporate innovative entrepreneurship education into higher education. Combining years of teaching experience in college mathematics and practical experience in carrying out college mathematics curriculum reform under the background of new engineering, in this paper, we put forward a new college mathematics teaching idea of “sticking to the problem orientation and highlighting the application of mathematics”, and emphasize the “triple combination” of college mathematics teaching mode covering students’ learning situation, learning content and teaching mode. The aiming is to cultivate college students’ mathematics application ability and innovative thinking ability, and improve the teaching effect in mathematics classroom.