Abstract: OBE teaching mode is in line with software engineering professional certification education mode, and it is a further improvement of ‘student-centered, output-oriented’, which can meet the needs of students to acquire knowledge and cultivate ability. To apply OBE teaching mode in the course of ‘Algorithm Design and Analysis’, it is necessary to reform teaching objectives and tasks, combine with competitions, promote ‘teacher-guided learning’ and online and offline mixed teaching methods, formulate long-term incentive mechanism, and construct an assessment method for students' comprehensive output. The OBE teaching mode can solve the current ‘pain point’ and ‘blocking point’ of the course, make curriculum teaching and personnel training closely combined, and then effectively achieve the graduation requirement. The results of practical application show that the reform has achieved obvious effects, and students' achievements in various algorithm competitions are obviously better than those before the reform.