Abstract: As a compulsory course of composite material and engineering, composite principle of materials is theoretical and practical, and it is very important in cultivating practical and innovative ability of students. Under the background of innovation and entrepreneurship education reform, it is necessary to carry out teaching reform and practice of composite principle of materials. According to the teaching status of composite principle of materials under the innovation and entrepreneurship education, the teaching content, teaching methods and assessment methods of the course were reformed, and the teaching effect and experience of curriculum reform were obtained. It was proposed to optimize the teaching content with the latest academic research cases or literature, enhance the application of theories with extracurricular design tasks, and examine the degree of improvement of knowledge and abilities through diversified assessment methods, so as to cultivate the comprehensive and innovative abilities of students. The survey results show that students who were educated in innovation and entrepreneurship reform were more likely to find strategies to solve professional technical problems, and more innovative in the comprehensive utilization of materials and design of composite materials.