Abstract: As an important hub in China’s urban economic development, the location of high-speed rail stations is bound to have a driving and facilitating effect on the development of the city’s economy. By starting from the perspective of how the location of high-speed railway stations affects the city economy, the decisive factors that directly affect the construction of high-speed railway stations are analyzed. Based on factor analysis and case argumentation, the influence of index factors such as urban development conditions, engineering conditions, operating conditions and policies on the location of high-speed railway passenger stations are comprehensively analyzed, and relevant suggestions are made.