Abstract: The reform of ideological and political education in the course is the inevitable requirement for the realization of moral education and the cultivation of talents. This paper pointed out that there were three problems in the ideological and political education in local universities, namely, the lack of teachers’ cognition and practice ability of ideological and political education, the lack of students’ comprehensive quality under the traditional training mode, and the impure learning motivation of students. Accordingly, theoretical measures were put forward, such as strengthening the construction of teachers’ ethics, strengthening the top-level design, practicing the innovative education mode of “talents + humanities”, and improving the important role of the course construction. Under the background of the epidemic situation, the new idea of ideological and political education in the course of “specialty+anti epidemic” by using the advantages of online teaching was shared, which made students deeply realize the importance of professional knowledge, enhance students’ concentration on professional courses learning, arouse students’ knowledge resonance, emotional resonance and value resonance, encourage the students to change their passive learning into active learning.