Abstract: Mould CAD/CAM is highly innovative and practical, which has a great advantage in cultivating students’ innovation and entrepreneurship ability and their practical ability. According to the characteristics of the course content and the disadvantages of the traditional teaching mode, the optimization and modular design of the teaching content, the reform of teaching methods and optimization of assessment methods were carried out in the paper. The innovation and entrepreneurship education concept was deeply integrated into the course teaching. By reform and practice of the course of mould CAD/CAM, the good results were achieved in cultivating students’ innovative entrepreneurial consciousness and practical ability. Also, it can be provided references for the construction of other professional courses.