Abstract: As an interdisciplinary course, nanomaterials and technology will introduce students to understand materials, materials fabrication and materials analysis based on nano scale via the combination the knowledge of physic, chemistry and materials. In this paper, teaching reform and practice of Nanomaterials and Technology for cultivating innovation ability and training divergent thinking were discussed based on the increasing innovation ability demanding for graduate education with economical transition and the characteristics of Materials Science and Technology. Firstly, the content of course is constructed mainly from three parts, such as nano scale, controllable assembly of atom or molecular, and nano characteristics by taking the construction, characteristic and property of nano scale as the main line. Case teaching method is used to cultivating innovation ability and deliberative teaching about advances and the famous research group over world in nanomaterials field is carried out through the flipped classroom to train divergent thinking. Trough six years teaching practice of nanomaterials and technology, it shows that masters trained by combining case teaching method and deliberative teaching method possess better innovation ability and divergent thinking than traditional teaching method. As a result, they show better innovation ability during their graduate study and subsequent career.