Abstract: Aiming at the characteristics of Mechanical Vibration course with strong theory, many formulas and abstract content, it is proposed to reform experimental teaching to stimulate students' interest in learning and improve teaching quality. An open and research-oriented experimental teaching mode be carry out. Based on the inertial reciprocating vibrating screen system as an example,, the mathematical model is established and simulated by Matlab software, and the experimental teaching of Mechanical Vibration Science is innovated. It is of great significance for students to solve practical problems and cultivate innovative consciousness.