Abstract: The integration of innovation and entrepreneurship education and professional education has become an inevitable trend in the reform of talent training mode in Colleges and universities, and the reform of talent training mode needs to rely on an effective curriculum carrier. Based on the characteristics of the course of sensor principle, which is very practical and comprehensive, in view of the problems existing in the course teaching, such as the old content of theoretical teaching, the lack of the combination of theory with practice, the rigidity of teaching methods and models, the lack of engineering training and the cultivation of innovation ability, a case teaching model for the course is put forward. The goal of this teaching model is to train the students’ ability of sensor application and innovation and entrepreneurship throughout the whole teaching process. Through the reform of teaching contents, teaching methods and examination forms, the students’ ability of independent learning, comprehensive application of knowledge and innovation and entrepreneurship have be improved and good results is achieved.