Abstract: "Nano materials and technology" course is an important course of material major. According to the principle of the unity of teaching and scientific research, the teaching innovation and practice including in teaching contents, teaching methods and assessment tools have been proceeded from the present teaching situation. The teaching contents should keep pace with the frontier, and the course website is built for learning. The students' creative thinking is trained by research teaching, and their abilities are comprehensively evaluated through PPT project defense examination. It has been tested in practice that the construction of creative classroom promotes the students' ability to solve problems, and has a positive effect on the training of innovative talents.