Abstract: This paper selects a certain interval of Wuhan metro line two and line four of the multi-tunnels for study, using the finite element software ANSYS to simulate, exploring vibration response of the surrounding buildings under the metro running。The result showed that the horizontal vibration intensity of all the floors increases with the increase of floor, vertical vibration amplitude is not intensive. In the first five floors, vertical vibration is stronger than the horizontal vibration. After the fifth floor, the level of acceleration peak in each floor increases significantly with the increase of floor. Moreover, a train running in a single tunnel, vibration intensity of all the floors increases with the increase of depth, and decreases with the increase of the horizontal distance from vibration source, but the influence on depth is more obvious than that of horizontal distance. The four trains running in four tunnels respectively, the horizontal vibration at each point which is in the interior of the building increases with the increase of distance from tunnel central line, showing no increase or decrease trend, but the vertical vibration intensity and peak displacement at this point which close to the tunnel are intensive than that far away from the tunnel.