Abstract: High-temperature components in aero-engines and gas turbines work under harsh conditions, such as high temperature, high pressure, high vibration and other complex working conditions. Under these conditions, alloys for high-temperature components need to maintain good mechanical properties for a long time. Nickel-based cast superalloys are widely used for high-temperature parts and components in aero-engines and gas turbines. Their stability and mechanical properties at high temperature are important factors to ensure long-term safe operation of these components. In the complex environment such as high temperature and high pressure, alloy materials will be subjected to repeated stress, resulting in fatigue damage. High-cycle fatigue is one of the main factors that lead to the failure of nickel-based superalloys. Because of repeated loading under high stress, microscopic cracks gradually expand in the materials, and their service life is greatly affected. Therefore, the research on high-cycle fatigue properties of nickel-based superalloys is particularly important. The occurrence of high-cycle fatigue is related to many factors, including the microstructure, stress level and surface defects of the alloys as well as test conditions. In the present work, the differences of high-cycle fatigue mechanisms of nickel-based cast superalloys at different temperature, and the rules and characteristics of different failure states and their effects on high-cycle fatigue of the alloys were discussed, which is of guiding significance for studying the service life rules of blade materials, improving their service time and reducing their research and development cycle.