Abstract: Taking powder superalloy FGH96 as the research object, a new life prediction model method based on damage mechanics theory was proposed. For different inclusion characteristics, the crack initiation of powder superalloy has different characterization parameters, and its numerical changes provide an idea for the life prediction of crack initiation. In the present work, the current research status of the life prediction of powder superalloys was analyzed, and then the damage evolution equation was used to formulate the life prediction model. The finite element software (ANSYS) was used to simulate the influence of different positions, sizes and shapes of inclusions on crack initiation, and the corresponding damage parameter distribution cloud maps were obtained. Substituting the obtained damage parameters into the calculation model, the fatigue life calculation results were obtained. Comparing the calculation results with experimental ones, the validity of the fatigue life prediction model was proved. The results showed that the damage parameter Y can well characterize the low cycle fatigue damage of the material; Under different experimental conditions (temperature, strain range and strain ratio), the established fatigue life prediction model of powder alloy FGH96 can well reflect the effect of inclusions on the fatigue life of powder superalloy.