Abstract: The metal/oxide interface is a key area that controls the reaction mechanism and macroscopic properties. The in-situ characterization method can be used to investigate the interface formation in real time, continuously and dynamically, which has a prominent academic significance and a great engineering value for the understanding of interface formation and its application. This paper summarizes the latest research work of in-situ characterization on metal/oxide interfaces with advanced technologies, especially focusing on the observing and analyzing interfacial morphology, interfacial reaction, interfacial stress and interfacial formation through in-situ transmission electron microscopy, in-situ synchrotron radiation technology and in-situ neutron technology.