Abstract: The multiaxial fatigue analysis of the wing structure is investigated based on CAE technology in this paper. In order to forecast the fatigue life of the wing structure accurately, the analysis of flying wing external load characteristic is carried out by FLUENT with the method of the combination of fluid mechanics and finite element analysis. The static of the wing structure is analyzed with the finite element software ABAQUS, the multiaxial fatigue of the wing structure based on the theory of Brown-Miller multiaxial fatigue is also analyzed by FE-SAFE. The fatigue life and weak position of the wing is obtained. In contrast with actual situation, the results indicate that this method can predict the fatigue life of the wing structure effectively, which provides a new way for the analysis of the wing structure, and reference for estimating the fatigue life of the wing when designing the airfoil.